1,2,4,5‐Tetrazine: Synthesis and Reactivity in [4+2] Cycloadditions
1,2,4,5‐Tetrazine: Synthesis and Reactivity in [4+2] Cycloadditions
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DOI：
10.1002/(sici)1099-0690(199812)1998:12
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发表时间：
1998-12
影响因子：
2.8
通讯作者：
J. Sauer;D. Heldmann;J. Hetzenegger;Josef Krauthan;H. Sichert;J. Schuster
中科院分区：
文献类型：
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作者：
J. Sauer;D. Heldmann;J. Hetzenegger;Josef Krauthan;H. Sichert;J. Schuster
报告了标题化合物作为逆型狄尔斯-阿尔德反应中4π组分的反应性的完整详细信息，包括动力学数据。在这些研究中，供体取代的炔、烯、供体取代和未取代的环烯、烯酮缩醛和缩胺以及几种环烯醇醚被用作亲双烯体。通过该方法可以容易地获得许多4-单取代和4，5-二取代的哒嗪。
Full details on the reactivity of the title compound as 4π component in inverse-type Diels–Alder reactions, including kinetic data, are reported. Donor-substituted alkynes, alkenes, donor-substituted and unsubstituted cycloalkenes, ketene acetals and aminals, as well as several cyclic enol ethers were used as dienophiles in these investigations. A number of 4-mono- and 4,5-disubstituted pyridazines can easily be obtained by this method.