CASP7 variants modify susceptibility to cervical cancer in Chinese women.
CASP7 variants modify susceptibility to cervical cancer in Chinese women.
复制标题
CASP7 变异改变了中国女性对宫颈癌的易感性。
DOI：
10.1038/srep09225
复制
发表时间：
2015-03-18
影响因子：
4.6
通讯作者：
Wei Q
中科院分区：
文献类型：
--
作者：
Shi TY;He J;Wang MY;Zhu ML;Yu KD;Shao ZM;Sun MH;Wu X;Cheng X;Wei Q
Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations between four potentially functional polymorphisms in CASP7 and cervical cancer risk and evaluated their locus-locus interaction effects on the risk. The genotype-phenotype correlation was performed by a generalized linear regression model. We found that the rs4353229 polymorphism was associated with cervical cancer risk (under a recessive model: crude OR = 1.20, 95% CI = 1.02–1.40). Compared with the TT genotype, the rs10787498GT genotype was associated with an increased cervical cancer risk (adjusted OR = 1.19, 95% CI = 1.00–1.41). Combination analysis showed that subjects with four putative risk genotypes had a 1.54-fold increased cancer risk, compared with those who carried three or less putative risk genotypes. We also observed significant locus-locus joint effects on the risk, which may be mediated by the polymorphisms regulating CASP7 mRNA expression. Subsequent multifactor dimensionality reduction and classification and regression tree analyses indicated that the CASP7 genotypes might have a locus-locus interaction effect that modulated cervical cancer risk. Out data suggest that CASP7 polymorphisms may interact to modify cervical cancer risk by a possible mechanism of regulating CASP7 mRNA expression.
登录
查看更多内容
丝裂原激活蛋白激酶 Tmk3 参与里氏木霉的高渗透压抗性、细胞壁完整性维护和纤维素酶生产调节
影响因子：
3.7
作者：
Wang M;Zhao Q;Yang J;Jiang B;Wang F;Liu K;Fang X
通讯作者：
Fang X
影响因子：
4.7
作者：
Liu, Chen-yu;Wu, Michael C.;Christiani, David C.
通讯作者：
Christiani, David C.
影响因子：
5.3
作者：
He, Jing;Qiu, Li-Xin;Li, Jin
通讯作者：
Li, Jin
影响因子：
3.8
作者：
Lee, Kyunghong;Lee, Min Ho;Kim, Yoon Suk
通讯作者：
Kim, Yoon Suk
DOI：
10.1073/pnas.0903103106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Hindorff, Lucia A.;Sethupathy, Praveen;Manolio, Teri A.
通讯作者：
Manolio, Teri A.