Viability of Homozygous Deficiencies in Somatic Cells of DROSOPHILA MELANOGASTER.

Viability of Homozygous Deficiencies in Somatic Cells of DROSOPHILA MELANOGASTER.
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果蝇体细胞纯合缺陷的活力。

DOI：
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发表时间：
1979
期刊：
Genetics
影响因子：
3.3
通讯作者：
A. Garcı́a
A. Garcı́a
中科院分区：
生物学2区
文献类型：
--
作者：
P. Ripoll;A. Garcı́a

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通过诱导有丝分裂重组，观察不同缺陷的纯合子细胞的生存能力。缺陷长度从2条到30条不等，分布在5个主要的染色体臂上。在30个样本中，10个缺陷是细胞活的。我们的研究结果表明，12%的基因组是细胞存活所必需的，这支持了之前对果蝇基因组中约5000个基因的估计。
The viability of cells made homozygous for different deficiencies by induced mitotic recombination was examined. The deficiencies varied in length from two to 30 polytene chromosome bands and were distributed over the five major chromosome arms. Among a sample of 30, ten deficiencies were cell viable. Our results show that 12% of the genome is necessary for cell survival, supporting previous estimates of about 5,000 genes in the genome of Drosophila.