DNA excision repair pathways
DNA excision repair pathways
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DOI：
10.1016/s0959-437x(97)80124-4
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发表时间：
1997-04-01
影响因子：
4
通讯作者：
Wood, RD
中科院分区：
文献类型：
--
作者：
Lindahl, T;Karran, P;Wood, RD
主要的DNA切除修复途径的内源性DNA损伤的碱基切除修复和核苷酸切除修复紫外线造成的DNA损伤已重建与纯化的哺乳动物蛋白质和这些修复机制的细节正在出现。类似的数据正在成为关于不匹配修复复制错误的纠正。基因敲除小鼠中单个DNA修复蛋白的缺失提供了这些因子在体内作用的信息，最近几种修复酶的三维结构解释了它们的详细作用模式。
The major DNA excision repair pathways of base excision repair for endogenous DNA lesions and nucleotide excision repair for DNA damage inflicted by ultraviolet light have been reconstructed with purified mammalian proteins and details of these repair mechanisms are emerging. Similar data are becoming available with regard to mismatch repair for correction of replication errors. Deletion of individual DNA repair proteins in knockout mice provides information on the roles of such factors in vivo and recent three-dimensional structures of several repair enzymes explain their detailed modes of action.