Renal effects of water-soluble polyarylsulfonated C60 in rats with an acute toxicity study
Renal effects of water-soluble polyarylsulfonated C60 in rats with an acute toxicity study
复制标题
DOI：
10.1080/15363839708013327
复制
发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Chiang, LY
中科院分区：
文献类型：
--
作者：
Chen, HHC;Yu, C;Chiang, LY
用幼龄雌性大鼠一次性腹腔注射C（60）（（CH（2））（4）SO（3）Na）（4-6），进行水溶性C（60）的急性毒性研究。初步结果表明，其LD（50）值约为600 mg/kg。该化合物可诱导一种独特的吞噬溶酶体超负荷肾病，可作为一系列合成水溶性富勒烯毒性筛选试验的生物标志物。
Acute toxicity study of water soluble C(60) was conducted in young female rats with one dose intraperitoneal injection of C(60) ((CH(2))(4)SO(3)Na)(4-6). The preliminary results indicated its LD(50) value as approximately 600 mg/kg. The compound induced a unique phagolysosome-overload nephropathy that may serve as a biological marker in toxicity screening test for a series of synthesized water-soluble fullerenes.