Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP.
Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP.
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DOI：
10.1021/mz5001724
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发表时间：
2014-05
影响因子：
5.8
通讯作者：
Qiang Zhang;P. Wilson;Athina Anastasaki;Ronan Mchale;D. Haddleton
中科院分区：
文献类型：
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作者：
Qiang Zhang;P. Wilson;Athina Anastasaki;Ronan Mchale;D. Haddleton
合成了一种无化学保护的含甘露糖的丙烯酸酯单体（ManA），并通过Cu（0）介导的自由基水溶液聚合（SET-LRP）进行了聚合。通过加入N-异丙基丙烯酰胺（NIPAm）或二甘醇乙醚丙烯酸酯（DEGEEA）溶液，实现了一锅法嵌段共聚，形成了温敏性双亲水性二嵌段共聚物，其在水溶液中显示出自组装特性，形成了定义明确的糖修饰纳米颗粒。
A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.