Construction of the six- and five-membered aza-heterocyclic units of the isoindoloisoquinolone nucleus by Parham-type cyclization sequences - Total synthesis of nuevamine
Construction of the six- and five-membered aza-heterocyclic units of the isoindoloisoquinolone nucleus by Parham-type cyclization sequences - Total synthesis of nuevamine
复制标题
DOI：
10.1002/ejoc.200500312
复制
发表时间：
2005-08-12
影响因子：
2.8
通讯作者：
Grandclaudon, P
中科院分区：
文献类型：
--
作者：
Moreau, A;Couture, A;Grandclaudon, P
介绍了一种有效的合成异吲哚并[1，2-a]异喹诺酮的方法，该方法基于两个Parham型环化反应，允许从氨基甲酸酯或二酰胺前体形成五元和六元含氮环。生物碱新瓦明的全合成进一步说明了该方法的合成潜力。((c)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2005）
An efficient methodology for the synthesis of isoindolo[1,2-a]isoquinolones based on two Parham-type cyclizations allowing the formation of the five- and six-membered nitrogenated rings from carbamate or diacylamine precursors is described. The synthetic potential of this method has been further illustrated by the total synthesis of the alkaloid nuevamine. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)