[Research progress in rotavirus VP4 subunit vaccine].
[Research progress in rotavirus VP4 subunit vaccine].
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DOI：
10.13345/j.cjb.160480
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发表时间：
2017-07-25
期刊：
影响因子：
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通讯作者：
Ge, Shengxiang
中科院分区：
文献类型：
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作者：
Jia, Lianzhi;Li, Tingdong;Ge, Shengxiang
轮状病毒是世界范围内5岁以下儿童急性腹泻的主要原因，造成严重的社会和经济负担。接种疫苗是控制轮状病毒感染的最有效方法，然而，在轮状病毒引起的死亡率较高的非洲和亚洲一些低收入国家，获得许可的轮状病毒疫苗效果不佳。此外，还有安全方面的担忧，如肠套叠风险增加。因此，提高轮状病毒疫苗的效率和安全性，降低轮状病毒引起的发病率和死亡率是当务之急。到目前为止，人们在提高轮状病毒疫苗的有效性方面做了很多努力，其中灭活疫苗成为轮状病毒疫苗研究的主要趋势。本文对重组轮状病毒疫苗，特别是VP4亚单位疫苗的研究进展进行了综述，以期为进一步研究开发有效的重组轮状病毒疫苗提供参考。
Rotaviruses are leading causes of worldwide acute diarrhea in children younger than 5 years old, with severe consequence of social and economic burden. Vaccination is the most effective way to control rotavirus infection, however, the licensed rotavirus vaccines are ineffective in some low-income countries of Africa and Asia, where the mortality caused by rotavirus is higher than other areas. In addition, there are also safety concerns such as increased risk of intussusception. Therefore, it is urgent to improve the efficiency and safety of rotavirus vaccine to reduce the morbidity and mortality caused by rotavirus. Till now, many efforts are made to improve the effectiveness of rotavirus vaccines, and the inactive vaccine becomes the main trend in the research of rotavirus vaccine. The developments in recombinant rotavirus vaccines, especially in VP4 subunit vaccines are summarized in this review, and it could be helpful to develop effective recombinant rotavirus vaccines in further studies.