Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations
Weight Loss after Roux-en-Y Gastric Bypass in Obese Patients Heterozygous for MC4R Mutations
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DOI：
10.1007/s11695-010-0295-8
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发表时间：
2011-07-01
期刊：
影响因子：
2.9
通讯作者：
Vaisse, Christian
中科院分区：
文献类型：
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作者：
Aslan, Ivy R.;Campos, Guilherme M.;Vaisse, Christian
黑皮质素-4受体（MC4R）的杂合突变是肥胖症最常见的遗传原因。减肥手术是治疗严重肥胖的一种成功方法。减肥手术后体重减轻的机制尚不清楚。92例接受Roux-en-Y胃旁路术（RYGB）手术的患者进行了MC4R突变筛查。我们比较了4例MC4R突变携带者与两个对照组的额外体重减轻百分比（%EWL）：8例匹配的对照组和其余80例接受RYGB的患者。在MC4R突变的患者中，RYGB后的%EWL（66%EWL）与匹配对照组（70%EWL）和非匹配对照组（60%EWL）相比，随访1年后无显著差异。本研究表明，杂合MC4R突变的患者也受益于RYGB，体重减轻可能与此类突变的存在无关。
Heterozygous mutations in melanocortin-4 receptor (MC4R) are the most frequent genetic cause of obesity. Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood.Ninety-two patients who had Roux-en-Y gastric bypass (RYGB) surgery were screened for MC4R mutations. We compared percent excess weight loss (%EWL) in the four MC4R mutation carriers with that of two control groups: 8 matched controls and with the remaining 80 patients who underwent RYGB.Four patients were heterozygous for functionally significant MC4R mutations. In patients with MC4R mutations, the %EWL after RYGB (66% EWL) was not significantly different compared to matched controls (70% EWL) and non-matched controls (60% EWL) after 1 year of follow-up.This study suggests that patients with heterozygous MC4R mutations also benefit from RYGB and that weight loss may be independent of the presence of such mutations.