Racial differences in the age-related increase in left ventricular mass in youths.
Racial differences in the age-related increase in left ventricular mass in youths.
复制标题
青少年左心室质量随年龄增加的种族差异。
DOI：
10.1161/01.hyp.24.6.747
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Becker,JA
中科院分区：
文献类型：
--
作者：
Harshfield,GA;Koelsch,DW;Pulliam,DA;Alpert,BS;Richey,PA;Becker,JA
我们在60名黑人（平均年龄13 +/-2岁）和40名白色（平均年龄14 +/-2岁）血压正常的年轻人中确定了与左心室质量相关的因素，并根据体型进行了调整。检查的因素包括年龄、性别、收缩压、舒张压、血浆肾素活性、血浆醛固酮浓度以及通过24小时排泄测定的钠和钾摄入量。性别（β = 13.3，P <0.003）、年龄（β = 2.88，P <0.001）和收缩压（β = 0.41，P <0.02）是样本整体的独立预测因素，占身高校正后左心室质量方差的37%。对黑人和白色受试者进行单独分析。在黑人受试者中，年龄（β = 4.4，P <0.004）和性别（β = 11.85，P <0.02）是独立因素，占身高校正后左心室质量方差的43%。相反，在白色受试者中，收缩压（β = 0.4，P <0.003）和钠排泄量（β = 0.13，P <0.05）是独立因素，性别（β = 8.89，P <0.07）倾向于解释36%的方差。经体表面积校正的左心室质量观察到类似的结果。总之，与年龄相关的黑人而非白色青年校正左心室质量的增加可能是黑人人群心血管疾病早期发展的部分原因。
We determined the factors related to left ventricular mass adjusted for body size in 60 black (mean age, 13 +/- 2 years) and 40 white (mean age, 14 +/- 2 years) normotensive youths. The factors examined included age, sex, systolic blood pressure, diastolic blood pressure, plasma renin activity, plasma aldosterone concentration, and sodium and potassium intake as determined by 24-hour excretion. Sex (beta = 13.3, P < .003), age (beta = 2.88, P < .001), and systolic blood pressure (beta = 0.41, P < .02) were independent predictors in the sample as a whole, accounting for 37% of the variance of left ventricular mass adjusted for height. Separate analyses were performed for black and white subjects. In the black subjects, age (beta = 4.4, P < .004) followed by sex (beta = 11.85, P < .02) were independent factors, accounting for 43% of the variance of left ventricular mass adjusted for height. In contrast, in white subjects systolic blood pressure (beta = 0.4, P < .003) followed by sodium excretion (beta = 0.13, P < .05) were independent factors, with gender (beta = 8.89, P < .07) tending to account for 36% of the variance. Similar results were observed for left ventricular mass adjusted for body surface area. In conclusion, the age-related increase in adjusted left ventricular mass in black but not white youths may in part account for the early development of cardiovascular disease among the black population.