RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus
RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus
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DOI：
10.1128/aac.44.11.3163-3166.2000
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发表时间：
2000-11-01
影响因子：
4.9
通讯作者：
Chopra, I
中科院分区：
文献类型：
--
作者：
O'Neill, A;Oliva, B;Chopra, I
研究人员将一系列具有特异RNA聚合酶-亚基（rpoB）基因突变的金黄色葡萄球菌利福平耐药突变体与其他RNA聚合酶抑制剂进行交叉筛选，以确定其易感性与特定rpoB基因型的相关性。rpoB突变体对链多溶血素和sorangicin A具有交叉抗性，而硫绿素、holomycin、corallopyronin A和ripostatin A对rpoB突变体具有抗性。第二组抑制剂可能是有兴趣的药物开发候选。
A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta -subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.