Executive functioning in preschool children born very preterm: Relationship with early white matter pathology
Executive functioning in preschool children born very preterm: Relationship with early white matter pathology
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DOI：
10.1017/s1355617708080053
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Woodward, Lianne J.
中科院分区：
文献类型：
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作者：
Edgin, Jamie O.;Inder, Terrie E.;Woodward, Lianne J.
尽管有证据表明学龄期早产儿存在执行功能障碍，但对这些困难的早期发展或其潜在的神经病理学知之甚少。本研究采用前瞻性纵向数据，从一个区域队列的88个极早产儿和98个足月对照儿童，检查执行功能（EF）的学龄前儿童出生极早产。研究新生儿大脑白色物质（WM）异常的严重程度与2岁和4岁（校正年龄）儿童EF之间的关系。在4岁时，即使在控制了儿童IQ和SES之后，WM异常的极早产儿童在迂回到达框（一种行为抑制和认知灵活性的测量）上的表现也不如足月儿童。医学背景。2至4岁之间的EF性能模式的检查表明，所有组的性能随着年龄的增长而提高。然而，轻度和中重度WM异常的极早产儿的特点是一致的性能障碍的发生率较高。这些研究结果支持存在早期和持续的执行困难的学龄前儿童出生非常早产，并强调了白色物质病理学的发展中的执行障碍的重要性。
Despite evidence for executive dysfunction in school-aged preterm children, less is known about the early development of these difficulties or their underlying neuropathology. This study used prospective longitudinal data from a regional cohort of 88 very preterm and 98 full-term comparison children to examine the executive functioning (EF) of preschool children born very preterm. The relationship between the severity of neonatal cerebral white matter (WM) abnormalities on magnetic resonance imaging (MRI) at term equivalent and children's EF at ages two and four years (corrected age) was examined. At age four, very preterm children with WM abnormalities performed less well than full-term children on the Detour Reaching Box, a measure of behavioural inhibition and cognitive flexibility, even after controlling for child IQ.SES. and medical background. Examination of patterns of EF performance between the ages of 2 and 4 years showed that the performance of all groups improved with age. However, very preterm children with mild and moderate-severe WM abnormalities were characterized by higher rates of consistent performance impairments. These findings support the presence of early and persistent executive difficulties in preschool children born very preterm, and highlight the importance of white matter pathology in the development of executive impairments.