Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients
Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients
复制标题
五脂胶囊对肾移植受者他克莫司血药浓度的影响
DOI：
10.12659/aot.918980
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发表时间：
2019-11-12
影响因子：
1.1
通讯作者：
Li, Yi
中科院分区：
文献类型：
--
作者：
Yan, Lin;Yang, Zhi-Qiang;Li, Yi
背景：他克莫司是肾移植受者广泛使用的免疫抑制剂。在大鼠和健康志愿者中证明，五脂胶囊可以抑制代谢并维持他克莫司的血药浓度。但目前尚无五酯胶囊在肾移植受者中的临床研究。本研究旨在评估五酯胶囊对肾移植受者中他克莫司血药浓度的影响。材料/方法：本回顾性研究纳入了158名接受他克莫司联合或不联合五酯胶囊治疗的中国肾移植受者。该队列研究包括 126 名接受者，其中 86 名接受者接受五脂胶囊 (WZC)，另外 40 名接受者未接受 WZC。另外 32 名受者参与了自我对照研究。结果：WZC 组中他克莫司的剂量和体重调整谷浓度 (C0/D/W) 显着高于非 WZC 组（P
Background: Tacrolimus is a widely used immunosuppressant in renal transplant recipients. It was demonstrated in rats and healthy volunteers that Wuzhi capsules could inhibit metabolism and maintain blood concentration of tacrolimus. However, there are no clinical studies of Wuzhi capsules in renal transplant recipients. This research aimed to assess the effect of Wuzhi capsules on the blood concentration of tacrolimus in renal transplant recipients.Material/Methods: A total of 158 Chinese renal transplant recipients receiving tacrolimus with or without Wuzhi capsules were included in this retrospective study. The cohort study included 126 recipients, with 86 recipients receiving Wuzhi capsules (WZCs) and the other 40 recipients not receiving WZCs. Another 32 recipients were involved in a self-control study.Results: Dose- and body weight-adjusted trough concentrations (C0/D/W) of tacrolimus in the WZC group were found to be significantly higher than that in the non-WZC group (P