EFFECT ON MICE OF INFECTION DURING PREGNANCY WITH 3 AUSTRALIAN ARBOVIRUSES
EFFECT ON MICE OF INFECTION DURING PREGNANCY WITH 3 AUSTRALIAN ARBOVIRUSES
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DOI：
10.4269/ajtmh.1981.30.198
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
DALGLISH, D
中科院分区：
文献类型：
--
作者：
AASKOV, JG;DAVIES, CEA;DALGLISH, D
在正常胎盘建立后，如果怀孕的小鼠感染罗斯河病毒或盖塔病毒，则会导致胎儿感染这些病毒。只有罗斯河病毒才有明显的胎儿死亡。宫内感染罗斯河病毒而未感染盖塔病毒的小鼠有显著的产后死亡率。尽管病毒不能通过胎盘，但感染墨累谷脑炎病毒的小鼠仍有显著的产后死亡率。在胎盘形成前(怀孕后第5天)感染罗斯河、盖塔或墨累谷脑炎病毒的小鼠不会导致胎儿感染，尽管感染罗斯河病毒的母亲所生的小鼠有显著的产后死亡。
Infection of pregnant mice with Ross River or Getah viruses after the establishment of a functional placenta resulted in fetal infection with these viruses. Only with Ross River virus was there any significant fetal death. There was significant postpartum mortality in mice infected in utero with Ross River but not with Getah virus. Significant postpartum mortality occurred in Murray Valley encephalitis virus-infected mice despite the inability of the virus to cross the placenta. Infection of mice with Ross River, Getah or Murray Valley encephalitis viruses before placentation had occurred (5th day postconception) did not result in fetal infection although there was significant postpartum death in litters born to Ross River virus-infected mothers.