Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies
Anti-HBV nucleotide prodrug analogs: Synthesis, bioreversibility, and cytotoxicity studies
复制标题
DOI：
10.1016/j.bmcl.2005.12.058
复制
发表时间：
2006-03-15
影响因子：
2.7
通讯作者：
Iyer, RP
中科院分区：
文献类型：
--
作者：
Padmanabhan, S;Coughlin, JE;Iyer, RP
已经合成了模型抗HBV二核苷酸3 '-dA-U-2' OMe的几种原核苷酸类似物，并评价了其稳定性、生物可逆性和细胞毒性。这些研究有助于确定进一步评价的潜在候选者。(C)2005爱思唯尔有限公司保留所有权利。
Several pronucleotide analogs of the model anti-HBV dinucleotide 3'-dA-U-2'OMe, have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation. (C) 2005 Elsevier Ltd. All rights reserved.