Predictors of Recurrence in Bipolar Disorder: Primary Outcomes From the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Predictors of Recurrence in Bipolar Disorder: Primary Outcomes From the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
复制标题
双相情感障碍复发的预测因素：双相情感障碍系统治疗强化计划 (STEP-BD) 的主要结果
DOI：
10.1176/foc.4.4.553
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
M. Thase
中科院分区：
文献类型：
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作者：
R. Perlis;M. Ostacher;J. Patel;L. Marangell;Hongwei Zhang;S. Wisniewski;T. Ketter;D. Miklowitz;M. Otto;L. Gyulai;N. Reilly;A. Nierenberg;G. Sachs;M. Thase
目的：根据当代实践指南，对接受治疗的双相情感障碍患者与复发风险相关的临床特征知之甚少。作者寻找与复发风险相关的特征。方法：作者检查了一组双相情感障碍患者的前瞻性数据，这些患者参加了长达24个月的多中心双相情感障碍系统治疗增强计划（STEPBD）研究。对于那些在进入研究时有症状但随后恢复的患者，采用考克斯回归分析研究至躁狂、轻躁狂、混合状态或抑郁发作复发的时间。结果：在进入研究时有症状的1，469名参与者中，858名（58.4%）随后恢复。在长达2年的随访中，这些人中有416人（48.5%）经历了复发，其中抑郁发作（298，34.7%）是躁狂，轻躁狂或混合发作（118，13.8%）的两倍多。
Objective: Little is known about clinical features associated with the risk of recurrence in patients with bipolar disorder receiving treatment according to contemporary practice guidelines. The authors looked for the features associated with risk of recurrence. Method: The authors examined prospective data from a cohort of patients with bipolar disorder participating in the multicenter Systematic Treatment Enhancement Program for Bipolar Disorder (STEPBD) study for up to 24 months. For those who were symptomatic at study entry but subsequently achieved recovery, time to recurrence of mania, hypomania, mixed state, or a depressive episode was examined with Cox regression. Results: Of 1,469 participants symptomatic at study entry, 858 (58.4%) subsequently achieved recovery. During up to 2 years of follow-up, 416 (48.5%) of these individuals experienced recurrences, with more than twice as many developing depressive episodes (298, 34.7%) as those who developed manic, hypomanic, or mixed episodes (118, 13.8%...