When observational studies can give wrong answers: the potential of immortal time bias
When observational studies can give wrong answers: the potential of immortal time bias
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DOI：
10.1530/eje-20-1124
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发表时间：
2021-01-01
影响因子：
5.8
通讯作者：
Groenwold, Rolf H. H.
中科院分区：
文献类型：
--
作者：
Dekkers, Olaf M.;Groenwold, Rolf H. H.
在观察性研究中，如果暴露状态是根据基线后发生的测量或事件确定的，则应始终考虑不朽时间偏差。这种偏差可能导致对效果的高估，也可能导致对效果的低估。说明了几种方法可以用来避免不朽的时间偏差在研究的分析阶段；与时间相关的分析可避免不朽的时间偏差，从而优化可用信息的使用。
Immortal time bias should always be considered in an observational study if exposure status is determined based on a measurement or event that occurs after baseline. This bias can lead to an overestimation of an effect, but also to an underestimation, which is explained. Several approaches are illustrated that can be used to avoid immortal time bias in the analysis phase of the study; a time-dependent analysis to avoid immortal time bias optimizes the use of available information.