EFFECTS OF MORINDA-LUCIDA LEAF EXTRACT ON TRYPANOSOMA BRUCEI BRUCEI INFECTION IN MICE
EFFECTS OF MORINDA-LUCIDA LEAF EXTRACT ON TRYPANOSOMA BRUCEI BRUCEI INFECTION IN MICE
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DOI：
10.1016/0378-8741(90)90109-7
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发表时间：
1990-10-01
影响因子：
5.4
通讯作者：
CHINEME, CN
中科院分区：
文献类型：
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作者：
ASUZU, IU;CHINEME, CN
用 50% 甲醇提取干燥的巴戟天叶子，回收提取物，收率为 9.7% w/w。小鼠急性毒性试验，提取物腹腔注射LD50为2000mg/kg。该提取物从口服后第一小时开始诱导小鼠通便，并在第三小时和第四小时之间达到峰值。通便不是剂量依赖性的。 M. lucida 叶提取物 i.p.显着抑制小鼠布氏锥虫感染后的寄生虫血症水平。腹腔注射 1000 mg/kg 时，对现有寄生虫血症的抑制似乎呈剂量依赖性。产生最大的效果。当用 M. lucida 提取物处理并同时开始锥虫抑制时，可获得最佳的杀锥虫活性。
The dried leaves of Morinda lucida were extracted with 50% methanol and the extract was recovered in a 9.7% w/w yield. Acute toxicity tests were performed in mice and the intraperitoneal LD50 of the extract was 2000 mg/kg. The extract induced purgation in mice from the first hour after oral administration and reached its peak between the third and fourth hour. The purgation was not dose-dependent. M. lucida leaf extract i.p. significantly suppressed the level of parasitemia after Trypanosoma brucei infection in mice. Suppression of existing parsitemia appeared dose-dependent with 1000 mg/kg i.p. producing the maximum effect. The best trypanocidal activity was obtained when treatment with M. lucida extract commenced simultaneously with trypanosome inhibition.