Wirelike micelle formed by a T-shaped graft copolymer with a rigid backbone
Wirelike micelle formed by a T-shaped graft copolymer with a rigid backbone
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DOI：
10.1021/ma035139j
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发表时间：
2004
期刊：
影响因子：
5.5
通讯作者：
Kwang Hee Kim;J. Huh;W. Jo
中科院分区：
文献类型：
--
作者：
Kwang Hee Kim;J. Huh;W. Jo
嵌段共聚物在其中一种嵌段的选择性溶剂中可以形成多种胶束结构，从球体、圆柱体或双层到更复杂的双连续结构。 1-3 这些结构可用于各种应用，例如药物载体4、5 和纳米多孔材料。 6, 7 在此类应用中，有必要设计嵌段共聚物的分子结构，以产生所需的胶束结构。事实上，分子结构是决定胶束形态的最重要的分子因素之一，因为它强烈影响与胶束结构的堆积几何形状相容的嵌段共聚物的构象限制。这里，分子结构由多种组成参数（例如，组成、序列等）和广泛的拓扑参数（例如，线性、刚性等）决定。许多早期的工作都集中在具有各种结构的柔性嵌段共聚物的胶束结构上，并揭示了疏水性嵌段的组成在决定胶束的形状和尺寸方面的重要性。 8-12 与对柔性嵌段共聚物胶束化的广泛研究相比，关于链刚性对胶束结构的影响的研究相对较少，特别是对于接枝共聚物等非线性链。 13 在本文中，我们通过布朗动力学模拟研究了由刚性主链和柔性侧链组成的两亲性 T 形接枝共聚物在对柔性侧链有选择性的溶剂中的胶束结构。特别是，这项工作重点研究接枝共聚物的主链刚性和链拓扑对接枝共聚物的构象限制如何影响胶束聚集体的堆积几何形状。
Block copolymer in a selective solvent for one of the blocks can form a variety of micellar structures, ranging from spheres, cylinders, or bilayers to more complex bicontinuous structures. 1-3 These structures can be used in various applications such as drug carriers4, 5 and nanoporous materials. 6, 7 In such applications, it is necessary to design the molecular structure of block copolymer that would yield a desired micellar structure. Indeed, the molecular architecture is one of the most important molecular factors in determining micellar morphology, since it strongly affects the conformational restriction of block copolymers compatible with the packing geometry of micellar structure. Here, the molecular architecture is determined by a variety of constitutional parameters (eg, composition, sequence, etc.) and a wide range of topological parameters (eg, linearity, rigidity, etc.). A number of earlier works have focused on the micellar structures of flexible block copolymers with various architectures and revealed the importance of the composition of hydrophobic block in determining the shape and size of the micelle. 8-12 In contrast to those extensive investigations on the micellization of flexible block copolymers, relatively few works have been conducted on the effect of chain rigidity on the micellar structure, particularly for nonlinear chain such as graft copolymer. 13 In this paper, we investigate the micellar structure of amphiphilic T-shaped graft copolymer consisting of a rigid backbone and a flexible side chain in a solvent selective for the flexible side chain by using a Brownian dynamics simulation. In particular, this work focuses on how the conformational restriction of the graft copolymer imposed by both backbone rigidity and chain topology of graft copolymer affects the packing geometry of micellar aggregates.