Early Continuous White Noise Exposure Alters Auditory Spatial Sensitivity and Expression of GAD65 and GABAA Receptor Subunits in Rat Auditory Cortex
Early Continuous White Noise Exposure Alters Auditory Spatial Sensitivity and Expression of GAD65 and GABAA Receptor Subunits in Rat Auditory Cortex
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DOI：
10.1093/cercor/bhp143
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发表时间：
2010-04-01
期刊：
影响因子：
3.7
通讯作者：
Sun, Xinde
中科院分区：
文献类型：
--
作者：
Xu, Jinghong;Yu, Liping;Sun, Xinde
感觉体验在哺乳动物听觉皮层的功能发育中发挥着重要作用。在这里，我们展示了早期连续噪音饲养如何影响大鼠初级听觉皮层（A1）的空间敏感性及其潜在机制。通过在连续、中等水平的白噪声条件下饲养幼鼠，我们发现噪声饲养显着减弱了 A1 神经元的空间敏感性。与正常条件下饲养的大鼠相比，A1神经元的尖峰计数受刺激位置变化的调节更差，并且它们的首选位置分布在更大的区域。我们进一步表明，早期连续噪音饲养导致谷氨酸脱羧酶65和γ-氨基丁酸（GABA）（A）受体α1亚基表达显着降低，以及GABA（A）受体α3表达增加，这表明GABA（A）受体恢复到幼年形式，但对N-甲基-D-天冬氨酸受体的表达没有影响。这些观察结果表明，噪音饲养对皮质 GABA 能抑制的成熟具有强大的不利影响，这可能是空间敏感性降低的原因。
Sensory experiences have important roles in the functional development of the mammalian auditory cortex. Here, we show how early continuous noise rearing influences spatial sensitivity in the rat primary auditory cortex (A1) and its underlying mechanisms. By rearing infant rat pups under conditions of continuous, moderate level white noise, we found that noise rearing markedly attenuated the spatial sensitivity of A1 neurons. Compared with rats reared under normal conditions, spike counts of A1 neurons were more poorly modulated by changes in stimulus location, and their preferred locations were distributed over a larger area. We further show that early continuous noise rearing induced significant decreases in glutamic acid decarboxylase 65 and gamma-aminobutyric acid (GABA)(A) receptor alpha 1 subunit expression, and an increase in GABA(A) receptor alpha 3 expression, which indicates a returned to the juvenile form of GABA(A) receptor, with no effect on the expression of N-methyl-D-aspartate receptors. These observations indicate that noise rearing has powerful adverse effects on the maturation of cortical GABAergic inhibition, which might be responsible for the reduced spatial sensitivity.