Nutritional geometry of mitochondrial genetic effects on male fertility
Nutritional geometry of mitochondrial genetic effects on male fertility
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DOI：
10.1098/rsbl.2019.0891
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发表时间：
2020-02-26
期刊：
影响因子：
3.3
通讯作者：
Reuter, M.
中科院分区：
文献类型：
--
作者：
Camus, M. F.;Moore, J.;Reuter, M.
器官健康部分取决于营养摄入与性别特异性代谢需求的匹配程度。代谢本身是由复杂的基因组相互作用，涉及来自核和线粒体基因组的产物。来自这两个基因组的产物必须协调营养物质的提取、使用和回收，这些过程对繁殖至关重要。鉴于代谢的复杂性，目前还不清楚这两个基因组的功能是如何被营养素调节的。在这里，我们使用营养几何技术的果蝇线，只有不同的线粒体DNA，目的是了解是否有营养依赖的线粒体遗传变异的男性生殖。我们首先发现饮食消费的遗传变异，表明苍蝇正在消耗不同数量的食物，以满足新的生理需求。然后，我们发现线粒体DNA和饮食之间的相互作用，健身，这表明线粒体DNA在调节饮食依赖的健身中发挥作用。我们的研究结果增强了我们对营养健康和嵌合基因组的基本理解。
Organismal fitness is partly determined by how well the nutritional intake matches sex-specific metabolic requirements. Metabolism itself is underpinned by complex genomic interactions involving products from both nuclear and mitochondrial genomes. Products from these two genomes must coordinate how nutrients are extracted, used and recycled, processes vital for fuelling reproduction. Given the complicated nature of metabolism, it is not well understood how the functioning of these two genomes is modulated by nutrients. Here we use nutritional geometry techniques on Drosophila lines that only differ in their mtDNA, with the aim to understand if there is nutrient-dependent mitochondrial genetic variance for male reproduction. We first find genetic variance for diet consumption, indicating that flies are consuming different amounts of food to meet new physiological requirements. We then find an interaction between mtDNA and diet for fitness, suggesting that the mtDNA plays a role in modulating diet-dependent fitness. Our results enhance our basic understanding of nutritional health and our chimeric genomes.