Histopathologic type: An independent prognostic factor in primary soft tissue sarcoma of the extremity?
Histopathologic type: An independent prognostic factor in primary soft tissue sarcoma of the extremity?
复制标题
DOI：
10.1245/aso.2003.05.014
复制
发表时间：
2003-05-01
影响因子：
3.7
通讯作者：
Brennan, MF
中科院分区：
文献类型：
--
作者：
Koea, JB;Leung, D;Brennan, MF
背景：我们试图明确肿瘤组织类型对手术治疗的原发肢体肉瘤患者局部复发、远处转移和疾病特异性生存的影响。方法：对951例原发局部软组织四肢肉瘤患者进行前瞻性随访。患者和肿瘤相关变量，包括组织病理学类型，被用来确定局部复发、远处复发和疾病特定生存的独立预后因素。结果：137例局部复发，局部复发的显著不良预后因素是患者年龄和50岁，切缘镜检阳性和恶性周围神经肿瘤。远处复发的不良预后因素(200例)是肿瘤大小<5厘米、包埋筋膜下肿瘤、高级别肿瘤和平滑肌肉瘤。在199例因疾病相关原因死亡的患者中，患者年龄和50岁、包埋筋膜下肿瘤、高级别肿瘤、镜检阳性边缘、肿瘤大小和5 cm、平滑肌肉瘤和恶性周围神经肿瘤是不良预后因素。结论：肉瘤组织类型之间可能存在生物学行为的差异，值得进一步研究。
Background: We attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma.Methods: A total of 951 patients with primary, localized soft tissue extremity sarcoma were followed up prospectively. patient- and tumor-related variables, including histopathologic type, were used to identify independent prognostic factors for the study end points of local recurrence, distant recurrence, and disease-specific survival.Results: There were 137 local recurrences, and significant adverse prognostic factors for local recurrence were patient age >50 years, microscopically positive margins, and malignant peripheral nerve tumor. Adverse prognostic factors for distant recurrence (200 patients) were tumor size >5 cm, tumors beneath the investing fascia, high tumor grade, and leiomyosarcoma. Of the 199 patients who died of disease-related causes, patient age >50 years, tumors beneath the investing fascia, high tumor grade, microscopically positive margin, tumor size >5 cm, leiomyosarcoma, and malignant peripheral nerve tumor were adverse prognostic factors.Conclusions: These data suggest that differences in biological behavior may exist between sarcoma histotypes and deserve further study.