The Analgesic Efficacy of Tramadol is Impaired by Concurrent Administration of Ondansetron
The Analgesic Efficacy of Tramadol is Impaired by Concurrent Administration of Ondansetron
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DOI：
10.1097/00000539-200105000-00045
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发表时间：
2001-05
影响因子：
5.7
通讯作者：
J. D. De Witte;B. Schoenmaekers;D. Sessler;T. Deloof
中科院分区：
文献类型：
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作者：
J. D. De Witte;B. Schoenmaekers;D. Sessler;T. Deloof
曲马多具有较弱的阿片类药物特性，其镇痛作用主要通过抑制去甲肾上腺素和5-羟色胺（5-羟色胺[5-HT]）的再摄取和促进5-HT在脊髓的释放（1,2）来介导。由于5-HT3受体在脊柱水平的疼痛传递中起关键作用(3)，5-HT3拮抗剂昂丹西琼可能会降低曲马多的疗效，Maroof等人在一篇摘要中指出。在该研究中，在麻醉诱导前15分钟，小剂量曲马多（1mg /kg）与昂丹司琼（0.1 mg/kg）或安慰剂一起使用。实验组间术后早期疼痛评分差异显著。因此，我们检验了患者自控镇痛（PCA）的曲马多需用量可能在昂丹司琼用于止吐预防时增加的假设。
Tramadol has weak opioid properties, and an analgesic effect that is mediated mainly by inhibition of the reuptake of norepinephrine and serotonin (5-hydroxytryptamine [5-HT]) and facilitation of 5-HT release (1,2) at the spinal cord. Because 5-HT3 receptors play a key role in pain transmission at the spinal level (3), the 5-HT3 antagonist ondansetron may decrease the efficacy of tramadol, as suggested in an abstract by Maroof et al. In that study, a small dose of 1 mg/kg tramadol was administered along with ondansetron 0.1 mg/kg or placebo, 15 min before the induction of anesthesia. Early postoperative pain scored differed significantly between the test groups. We therefore tested the hypothesis that the tramadol requirement by patient-controlled analgesia (PCA) may be increased when ondansetron is administered for antiemetic prophylaxis.