Enantioselective Organocatalytic C-H Bond Functionalization via Tandem 1,5-Hydride Transfer/Ring Closure: Asymmetric Synthesis of Tetrahydroquinolines
Enantioselective Organocatalytic C-H Bond Functionalization via Tandem 1,5-Hydride Transfer/Ring Closure: Asymmetric Synthesis of Tetrahydroquinolines
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DOI：
10.1021/ja103786c
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发表时间：
2010-09-01
影响因子：
15
通讯作者：
Kim, Dae Young
中科院分区：
文献类型：
--
作者：
Kang, Young Ku;Kim, Sun Mi;Kim, Dae Young
报道了第一个有机催化的对映选择性分子内1，5-氢化物转移/闭环反应。该氧化还原中性反应级联允许以高对映选择性有效形成环稠合的四氢喹啉。
The first organocatalytic enantioselective intramolecular 1,5-hydride transfer/ring closure reaction is described. This redox neutral reaction cascade allows for the efficient formation of ring-fused tetrahydroquinolines in high enantioselectivities.