Modular organization of the multipartite central pattern generator for turtle rostral scratch: knee-related interneurons during deletions.
Modular organization of the multipartite central pattern generator for turtle rostral scratch: knee-related interneurons during deletions.
复制标题
用于海龟喙划痕的多部分中央模式生成器的模块化组织：删除过程中与膝盖相关的中间神经元。
DOI：
10.1152/jn.00871.2015
复制
发表时间：
2016
影响因子：
2.5
通讯作者：
Corman,TanyaS
中科院分区：
文献类型：
--
作者：
Stein,PaulSG;Daniels-McQueen,Susan;Lai,Jessica;Liu,Z;Corman,TanyaS
中枢模式发生器（CPG）是脊髓中的神经元网络，在缺乏运动相关的感觉反馈的情况下产生运动活动的节律模式。对于许多脊椎动物的节律性行为，CPG 会生成运动神经元活动的正常模式以及正常模式的变化（称为缺失），其中一个或多个运动神经的爆发在一个或多个节律周期中不存在。先前对乌龟喙部抓伤过程中髋部伸肌缺失的研究支持了髋部伸肌模块中的髋部伸肌中间神经元和髋部屈肌模块中的髋部屈肌中间神经元的假设。我们在这里提出单单元中间神经元记录数据，支持膝伸肌模块中的膝伸肌中间神经元和膝屈肌模块中的膝屈肌中间神经元的假设。膝盖相关模块的成员不是臀部相关模块的成员，反之亦然。海龟中的这些结果为海龟后肢的头侧抓 CPG 是多部分的，即由两个以上模块组成的组织概念提供了单单元间神经元水平的实验支持。这项工作与其他脊椎动物的实验和计算工作相结合，并不支持经典观点，即脊椎动物肢体 CPG 是二分的，只有两个模块，一个控制肢体的所有屈肌，另一个控制肢体的所有伸肌。相反，这些结果支持脊柱 CPG 是多部分的一般原则。
Central pattern generators (CPGs) are neuronal networks in the spinal cord that generate rhythmic patterns of motor activity in the absence of movement-related sensory feedback. For many vertebrate rhythmic behaviors, CPGs generate normal patterns of motor neuron activities as well as variations of the normal patterns, termed deletions, in which bursts in one or more motor nerves are absent from one or more cycles of the rhythm. Prior work with hip-extensor deletions during turtle rostral scratch supports hypotheses of hip-extensor interneurons in a hip-extensor module and of hip-flexor interneurons in a hip-flexor module. We present here single-unit interneuronal recording data that support hypotheses of knee-extensor interneurons in a knee-extensor module and of knee-flexor interneurons in a knee-flexor module. Members of knee-related modules are not members of hip-related modules and vice versa. These results in turtle provide experimental support at the single-unit interneuronal level for the organizational concept that the rostral-scratch CPG for the turtle hindlimb is multipartite, that is, composed of more than two modules. This work, when combined with experimental and computational work in other vertebrates, does not support the classical view that the vertebrate limb CPG is bipartite with only two modules, one controlling all the flexors of the limb and the other controlling all the extensors of the limb. Instead, these results support the general principle that spinal CPGs are multipartite.