The nature of gliomas as revealed by animal experimentation.
The nature of gliomas as revealed by animal experimentation.
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动物实验揭示了神经胶质瘤的性质。
DOI：
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发表时间：
1955
影响因子：
6
通讯作者：
H. M. Zimmerman
中科院分区：
文献类型：
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作者：
H. M. Zimmerman
原发性颅内肿瘤占人体所有肿瘤的2%至5%。在这些肿瘤中，略少于一半属于神经胶质瘤组。后者包括至少七个普遍认可的独特类型以及一些相关的亚型。主要的类型有：星形细胞瘤、星形母细胞瘤、室管膜瘤、多形性胶质母细胞瘤、髓母细胞瘤、少突胶质细胞瘤和极性胶质母细胞瘤。这些亚型包括室管膜母细胞瘤、神经节细胞瘤和髓上皮瘤。神经胶质瘤的鉴别和分类问题并不简单，主要有两个原因。一是神经外科病理学仍处于早期发展阶段，主要关注描述性形态学和寻找新的肿瘤类型进行分类。因此，将星形细胞瘤分为毛样型、胞浆型和原生质型仍被认为是一种成就，尽管这种肿瘤的组织发生和生物学行为似乎并不支持这样的亚分类。另一个是，一个非常复杂的术语已经发展起来，这极大地阻碍了该领域的学生。目前的概念也是一组复杂和困难的染色技术是必不可少的各种胶质瘤的识别。普通病理学家回避神经外科病理学领域，因为他相信颅内肿瘤几乎难以克服的复杂性。
Primary intracranial neoplasms in man comprise from 2 to 5 per cent of all tumors in the body. Of these neoplasms, somewhat less than half belong to the glioma group. The latter comprises at least seven universally recognized, distinctive types as well as a number of related subtypes. The major types are: astrocytoma, astroblastoma, ependymoma, gioblastoma multiforme, medulloblastoma, oligodendroglioma, and spongioblastoma polare. To the subtypes belong, among others, the ependymoblastomas, ganglioneuromas, and medullo-epitheliomas. The problem of identification and classification of tumors of the glioma variety has not been simple, mainly for two reasons. One is that neurosurgical pathology is still in that early developmental stage which is preoccupied with descriptive morphology and with finding new tumor types to classify. Thus it is still considered somewhat of an achievement to have divided the astrocytoma into the piloid, fibrillary, and protoplasmic types, even though the histogenesis and biologic behavior of this tumor does not seem to warrant such subclassification. The other is that a vastly complicated terminology has developed which has greatly discouraged students in this field. The concept is also current that a battery of complicated and difficult staining techniques is essential for the identification of the various gliomas. The general pathologist has shunned the field of neurosurgical pathology because of his belief in the almost insurmountable complexity of the intracranial neoplasms.