A ROLE FOR THE MINERALOCORTICOID RECEPTOR IN A RAPID AND TRANSIENT SUPPRESSION OF HIPPOCAMPAL 5-HT1A RECEPTOR MESSENGER-RNA BY CORTICOSTERONE
A ROLE FOR THE MINERALOCORTICOID RECEPTOR IN A RAPID AND TRANSIENT SUPPRESSION OF HIPPOCAMPAL 5-HT1A RECEPTOR MESSENGER-RNA BY CORTICOSTERONE
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DOI：
10.1111/j.1365-2826.1995.tb00804.x
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发表时间：
1995-08-01
影响因子：
3.2
通讯作者：
DEKLOET, ER
中科院分区：
文献类型：
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作者：
MEIJER, OC;DEKLOET, ER
在雄性大鼠中研究皮质酮与海马5-HT 1A受体mRNA表达之间的相互作用。肾上腺切除后2d，齿状回颗粒细胞层5-HT 1A受体mRNA表达增加，皮质酮注射可引起5-HT 1A受体mRNA的剂量依赖性抑制。低剂量皮质酮（50 μ g/kg）的作用可被RU 28318（一种特异性盐皮质激素受体拮抗剂）阻断，但不能被RU 38486（一种糖皮质激素拮抗剂）阻断。较高剂量皮质酮（300 μ g/kg）的作用可被RU 28318部分阻断，而RU 38486则无额外作用。这些结果表明，海马5-HT 1A受体的皮质酮，主要是由盐皮质激素受体介导的严格监管。
The interaction between corticosterone and hippocampal 5-HT1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5-HT1A receptor mRNA was increased in the granule cell layer of the dentate gyrus, injection of corticosterone led to a significant dose-dependent and transient suppression of 5-HT1A receptor mRNA. The effect of a low dose of corticosterone (50 mu g/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist. The effect of a higher dose of corticosterone (300 mu g/kg) could be partially blocked by RU 28318, whereas there was no additional effect of RU 38486. These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.