Green tea consumption and the risk of pancreatic cancer in Japanese adults
Green tea consumption and the risk of pancreatic cancer in Japanese adults
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DOI：
10.1097/mpa.0b013e318160a5e2
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发表时间：
2008-07-01
期刊：
影响因子：
2.9
通讯作者：
Ishibashi, Teruo
中科院分区：
文献类型：
--
作者：
Lin, Yingsong;Kikuchi, Shogo;Ishibashi, Teruo
目的：绿茶多酚在动物体内和体外实验中均显示出抑制肿瘤生长的作用。我们在日本的一个大队列中调查了绿茶消费与胰腺癌死亡风险之间的关系。方法：在基线(1988-1990)，研究参与者报告了过去一年中绿茶消费的频率和数量。对他们的死亡率进行了跟踪调查，直到2003年12月31日。根据Cox比例风险模型计算相对危险度和95%可信区间。结果：在平均13年的随访中，我们观察到292例胰腺癌死亡。在男性和女性加在一起，在调整了潜在的混杂因素后，每天喝7杯或更多绿茶的参与者与每天喝不到1杯绿茶的参与者相比，相对风险为1.23(95%可信区间，0.84-1.80)。没有注意到随着绿茶消费的增加，风险降低的显著趋势。我们发现，在男性和女性中，每天饮用绿茶与胰腺癌风险之间没有负相关。结论：我们的发现不支持绿茶消费与人类胰腺癌风险降低相关的假设。
Objective: Green tea polyphenols have been shown to inhibit tumor growth in animal and in vitro studies. We examined the relationship between green tea consumption and the risk of death from pancreatic cancer in a large Japanese cohort.Methods: At baseline (1988-1990), study participants reported the frequency and amount of green tea consumption during the past year. They were followed-up for mortality until December 31, 2003. Relative risk and 95% confidence intervals were calculated from Cox proportional hazard models.Results: During an average follow-up of 13 years, we observed 292 pancreatic cancer deaths. In men and women combined, the relative risk was 1.23 (95% confidence interval, 0.84-1.80) for participants who consumed 7 or more cups of green tea per day as compared with those who consumed less than 1 cup per day, after adjustment for potential confounding factors. No significant trend in risk reduction was noted, with increasing consumption of green tea. We found no inverse association between cups of green tea consumed per day and the risk of pancreatic cancer in either men or women.Conclusions: Our findings do not support the hypothesis that green tea consumption is associated with decreased risk of pancreatic cancer in humans.