Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring
Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring
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DOI：
10.1038/cr.2016.144
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发表时间：
2016-12
期刊：
影响因子：
44.1
通讯作者：
Shuo Wang;Shuai Hong;Yongqiang Deng;Qing Ye;Ling-Zhai Zhao;Fu-chun Zhang;C. Qin;Zhiheng Xu
中科院分区：
文献类型：
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作者：
Shuo Wang;Shuai Hong;Yongqiang Deng;Qing Ye;Ling-Zhai Zhao;Fu-chun Zhang;C. Qin;Zhiheng Xu
寨卡病毒（ZIKV）正在全球60多个国家迅速传播。人们越来越关注ZIKV感染与胎儿和新生儿小头畸形病例的毁灭性病例的关联[1]。ZIKV感染和小头畸形之间的联系首先基于小头畸形胎儿脑组织中ZIKV的存在而提出[1]。最近在动物模型和人类脑类器官中证实了ZIKV感染和小头畸形之间的因果关系[2-4]。感染可能导致与神经祖细胞（NPC）发育、细胞死亡和免疫应答相关的基因失调，以及随后的小头畸形[2-4] AIKV疫苗可能需要数年时间，因此迫切需要探索立即可用的治疗剂以有效治疗ZIKV。在过去的几十年中，从疾病恢复的患者中获得的人恢复期血浆已被用于紧急应对新出现的病毒性疾病，如严重急性呼吸综合征、H5 N1流感、埃博拉病毒病和中东呼吸综合征[5]。值得注意的是，恢复期血浆对孕妇和儿童是安全的。在此，我们描述了在已建立的小头畸形动物模型中使用人恢复期血清治疗的效果[2]。
Zika virus (ZIKV) is spreading rapidly around the world in over 60 countries. There is a mounting concern over the association of ZIKV infection and devastating cases of fetal and newborn microcephaly cases [1]. The connection between ZIKV infection and microcephaly was first proposed based on the presence of ZIKV in microcephalic fetal brain tissues [1]. The causal link between ZIKV infection and microcephaly was recently confirmed in animal models and human cerebral organoids [2-4]. The infection is likely to cause deregulation of genes related to neural progenitor cell (NPC) development, cell death and immune response, and subsequently microcephaly [2-4].As a ZIKV vaccine is likely years away, there is an urgent need to explore immediately available therapeutics for effective treatment against ZIKV. Over the past decades, human convalescent plasma derived from patients recovered from diseases has been used in emergency response to emerging viral diseases, such as severe acute respiratory syndrome, H5N1 influenza, Ebola virus disease and Middle East respiratory syndrome [5]. Notably, convalescent plasma is safe for pregnant women and children. Here we describe the effects of treatment with human convalescent serum in an established animal model of microcephaly [2].