CpG Island Chromatin Is Shaped by Recruitment of ZF-CxxC Proteins
CpG Island Chromatin Is Shaped by Recruitment of ZF-CxxC Proteins
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DOI：
10.1101/cshperspect.a018648
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Skene, Peter J.
中科院分区：
文献类型：
--
作者：
Blackledge, Neil P.;Thomson, John P.;Skene, Peter J.
大多数哺乳动物基因启动子嵌入在称为CpG岛的基因组区域中，其特征是非甲基化CpG二核苷酸水平升高。在这里，我们描述了最近的工作，证明CpG岛作为锌指CxxC结构域蛋白CFP1和KDM2A的特定成核位点。重要的是，CFP1和KDM2A都与调节特定组蛋白赖氨酸甲基化标记的酶活性相关。因此，这些锌指CxxC结构域蛋白的作用在CpG岛上施加了一种确定的染色质结构，将这些重要的调控元件与周围的基因组区分开来。讨论了这种CpG岛导向染色质环境的功能后果。
Most mammalian gene promoters are embedded within genomic regions called CpG islands, characterized by elevated levels of nonmethylated CpG dinucleotides. Here, we describe recent work demonstrating that CpG islands act as specific nucleation sites for the zinc finger CxxC domain-containing proteins CFP1 and KDM2A. Importantly, both CFP1 and KDM2A are associated with enzymatic activities that modulate specific histone lysine methylation marks. The action of these zinc finger CxxC domain proteins therefore imposes a defined chromatin architecture on CpG islands that distinguishes these important regulatory elements from the surrounding genome. The functional consequence of this CpG island-directed chromatin environment is discussed.