Experimental transmission of influenza virus infection in mice. IV. Relationship of transmissibility of different strains of virus and recovery of airborne virus in the environment of infector mice.
Experimental transmission of influenza virus infection in mice. IV. Relationship of transmissibility of different strains of virus and recovery of airborne virus in the environment of infector mice.
复制标题
小鼠流感病毒感染的实验传播。 iv。不同菌株病毒菌株的可传播性与感染小鼠环境中空气传播病毒的恢复的关系。
DOI：
10.1084/jem.125.3.479
复制
发表时间：
1967-03-01
影响因子：
15.3
通讯作者：
Schulman, J L
中科院分区：
文献类型：
--
作者：
Schulman, J L
一只老鼠改编的日本鬼子。305株流感A2病毒被发现比NWS株A0流感病毒更容易从一只小鼠传播到另一只小鼠，尽管根据肺部病毒滴度和肺部病变判断，这两种病毒对小鼠的致病性相同。对于这两种病毒，人工制造的病毒气雾剂的存活率和启动小鼠感染所需的空气传播病毒的数量是相同的。传播力的差异与感染JAP的小鼠环境中传染性空气传播病毒的恢复有关。305株在其最大感染力期间，但在感染NWS株的小鼠的环境中不存在。
A mouse-adapted Jap. 305 strain of influenza A2 virus was found to be much more readily transmitted from one mouse to another than the NWS strain of influenza A0 virus although the two viruses were equally pathogenic for mice as judged by pulmonary virus titers and lung lesions. The survival of artificially created aerosols of virus and the quantity of airborne virus required to initiate infection in mice were identical for the two viruses. The difference in transmissibility was associated with the recovery of infectious airborne virus in the environment of mice infected with the Jap. 305 strain during the period of their maximum infectiousness, but not in the environment of mice infected with the NWS strain.