Kidney Function and White Matter Disease in Young Stroke Patients Analysis of the Stroke in Young Fabry Patients Study Population
Kidney Function and White Matter Disease in Young Stroke Patients Analysis of the Stroke in Young Fabry Patients Study Population
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DOI：
10.1161/strokeaha.111.645713
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发表时间：
2012-09-01
期刊：
影响因子：
8.3
通讯作者：
Jungehulsing, Gerhard Jan
中科院分区：
文献类型：
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作者：
Steinicke, Robert;Gaertner, Beate;Jungehulsing, Gerhard Jan
背景和目的：在普通中风人群中，肾功能受损被认为与小血管疾病、预后和死亡率有关。关于年轻患者的数据有限。本研究的目的是探讨青年首发缺血性卒中患者的肾功能与脑白质高信号(WMH)的关系。方法：我们分析了2500名青年(18-55岁)首次缺血性卒中患者，这些患者来自青年Fabry卒中患者前瞻性观察性研究(SIFAP1)，利用WMH的MRI数据进行分析。其中，2009年有关于估计肾小球滤过率(EGFR)的可用数据。肾功能用肾病饮食改良法表示为EGFR。MRI上深部WMH按Fazekas评分进行分类。结果WMH 0~1级(无至轻度)、2级(中度)、3级(重度)患者的平均EGFR分别为96.7mL/min、90.7mL/min、89mL/min。单因素分析显示WMH与年龄有关(P
Background and Purpose-Impaired kidney function is thought to be associated with small vessel disease, outcome, and mortality in the general stroke population. Data are limited regarding young patients. The aim of this study was to investigate the association of kidney function and white matter hyperintensities (WMHs) in young patients with first ischemic stroke.Methods-We analyzed 2500 young (18-55 years) patients with first-ever ischemic stroke from the prospective observational Stroke in Young Fabry Patients (SIFAP1) study with available MRI data on WMH. Of these, 2009 had available data concerning estimated glomerular filtration rate (eGFR). Kidney function was expressed as eGFR by the Modification of Diet in Renal Disease method. Deep WMHs on MRI were classified by the Fazekas score. Multivariate analysis was performed using a regression model with random effects.Results-Mean eGFR was 96.7 mL/min in those with WMH Grade 0 to 1 (none to mild), 90.7 mL/min in WMH Grade 2 (moderate), and 89 mL/min in WMH Grade 3 (severe). Univariate analysis revealed WMH to be associated with age (P