Microfluidic device to culture 3D in vitro human capillary networks.
Microfluidic device to culture 3D in vitro human capillary networks.
复制标题
用于体外培养 3D 人体毛细血管网络的微流体装置。
DOI：
10.1007/7651_2013_36
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
George,StevenC
中科院分区：
文献类型：
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作者：
Moya,MonicaL;Alonzo,LuisF;George,StevenC
旨在概括微循环动态活体特征的模型对于研究血管形成至关重要。细胞素活着不仅对生化信号(如生长因子梯度)作出反应，而且还能感觉到机械信号(如间质流动、血管灌流)。在动态的3D环境中整合细胞、间质和循环的反应，将创造一个适合探索许多基本血管形成过程的环境。在本章中，我们描述了一种体内激发的微环境，这种微环境有利于灌流的人类毛细血管的发育。
Models that aim to recapitulate the dynamicin vivofeatures of the microcirculation are crucial for studying vascularization. Cellsin vivorespond not only to biochemical cues (e.g., growth factor gradients) but also sense mechanical cues (e.g., interstitial flow, vessel perfusion). Integrating the response of cells, the stroma, and the circulation in a dynamic 3D setting will create an environment suitable for the exploration of many fundamental vascularization processes. Here in this chapter, we describe anin vivo-inspired microenvironment that is conducive to the development of perfused human capillaries.