Quantitative histology of muramyl dipeptide-potentiated induction of tumor necrosis by endotoxins
Quantitative histology of muramyl dipeptide-potentiated induction of tumor necrosis by endotoxins
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内毒素增强胞壁酰二肽诱导肿瘤坏死的定量组织学
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
F. Hofhuis
中科院分区：
文献类型：
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作者：
C. Kuper;N. Bloksma;J. Bruyntjes;F. Hofhuis
室壁二肽(MDP)与毒性或解毒的内毒素联合应用可诱导同基因小鼠Meth A实体瘤的坏死和随后消失。单靠有毒的内毒素效果要差得多。MDP和解毒内毒素本身的抗肿瘤作用可以忽略不计。这些观察结果得到了组织学检查的证实。与生理盐水组相比，静脉给药后4、24和48h，MDP和解毒内毒素均未引起肿瘤及其周围的明显改变。MDP能增强毒性内毒素的各种作用，如引起充血、有丝分裂停止、肥大细胞耗竭、非出血性坏死和淋巴细胞浸润减少，但不影响出血性坏死或多形核白细胞的内流。MDP和解毒内毒素联合用药缺乏后两种作用，但其他作用相似，但比联合用药略弱。由于充血程度与随后的非出血性坏死的程度成正比，MDP似乎通过加强导致充血的机制来加强坏死，肥大细胞介质可能参与了后者的作用。淋巴细胞的流入和治疗结果很可能是相关的，因为单独的治疗减少了这些细胞的流入。
SummaryCombinations of muramyl dipeptide (MDP) and toxic or detoxified endotoxin induced necrosis and subsequent disappearance of solid Meth A tumors in syngeneic mice. Toxic endotoxin alone was far less effective. MDP and detoxified endotoxin had negligible antitumor effects of their own. These observations were confirmed by histological examination. Neither MDP nor detoxified endotoxin induced significant changes in and around the tumor by 4, 24, and 48 h after intravenous administration when compared with saline treatment. MDP amplified various effects of toxic endotoxin such as the induction of hyperemia, mitotic arrest, mast cell depletion, non-hemorrhagic necrosis and reduction in lymphocyte infiltrates, but did not affect hemorrhagic necrosis or the influx of polymorphonuclear leukocytes. The combination of MDP and detoxified endotoxin lacked the latter two effects, but the other effects were similar to, although slightly less marked than those induced by the toxic combination. Because the degree of hyperemia was proportional to the degree of subsequent non-hemorrhagic necrosis, MDP seems to potentiate necrosis by enhancing mechanisms leading to hyperemia and mast cell mediators might be involved in the latter effect. Lymphocyte influx and the therapeutic outcome are likely to be related, since exclusively therapeutic treatments reduced the influx of these cells.
5-羟色胺对大鼠肿瘤组织血流和微波加热的影响。
影响因子：
11.2
作者：
Shrivastav,S;Joines,WT;Jirtle,RL
通讯作者：
Jirtle,RL