Cholinergic synapses in human cerebral cortex: an ultrastructural study in serial sections.
Cholinergic synapses in human cerebral cortex: an ultrastructural study in serial sections.
复制标题
人类大脑皮层的胆碱能突触：连续切片的超微结构研究。
DOI：
10.1006/exnr.1997.6413
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Mesulam,MM
中科院分区：
文献类型：
--
作者：
Smiley,JF;Morrell,F;Mesulam,MM
Cholinergic axons in the human cerebral cortex were analyzed by electron microscopy. Choline acetyltransferase (ChAT) immunoreactivity was used to identify cholinergic axons in samples of anterior temporal lobe removed at surgery. A systematic survey of labeled axon varicosities, visualized in complete serial sections, showed that 67% of all varicosities formed identifiable synaptic specializations. These synapses were usually symmetric and quite small, often present in only one to two serial sections. However, an occasional synapse was asymmetric and larger, seen in five to seven serial sections. The postsynaptic processes at cholinergic synapses were often identified as spiny dendrites or spines. The existence of cholinergic axons in the human cerebral cortex has been demonstrated in numerous studies. Our findings provide the first ultrastructural evidence that these axons make synaptic contact with cortical neurons in the human brain.
