The roles of therapy-induced autophagy and necrosis in cancer treatment
The roles of therapy-induced autophagy and necrosis in cancer treatment
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DOI：
10.1158/1078-0432.ccr-07-1595
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发表时间：
2007-12-15
影响因子：
11.5
通讯作者：
Thompson, Craig B.
中科院分区：
文献类型：
--
作者：
Amaravadi, Ravi K.;Thompson, Craig B.
代谢和治疗应激激活调节癌细胞中细胞死亡和细胞存活的几种信号转导途径。虽然几十年的研究揭示了调节细胞凋亡的途径，并允许在癌症治疗中开发新的诊断和治疗模式，但直到最近，肿瘤细胞自噬和坏死的调节和意义才成为研究的焦点。坏死是细胞死亡的不可逆炎症形式。相比之下，自噬是一个可逆的过程，可以促进肿瘤细胞的死亡和存活。本文综述了自噬和坏死的调控及其对癌症治疗的影响。目前可用的方法来衡量自噬和坏死的重点。探讨了肿瘤细胞自噬和坏死对宿主免疫功能的影响。最后，描述了靶向癌症中的自噬和坏死的治疗方法。
Metabolic and therapeutic stresses activate several signal transduction pathways that regulate cell death and cell survival in cancer cells. Although decades of research unraveled the pathways that regulate apoptosis and allowed the development of novel diagnostic and therapeutic modalities in cancer treatment, only recently has the regulation and significance of tumor cell autophagy and necrosis become the focus of investigations. Necrosis is an irreversible inflammatory form of cell death. In contrast, autophagy is a reversible process that can contribute both to tumor cell death and survival. This review describes recent advances in understanding the regulation of autophagy and necrosis and their implications for cancer therapy. Currently available methods to measure autophagy and necrosis are highlighted. The effect of tumor cell autophagy and necrosis on host immunity is explored. Finally, therapeutic approaches that target autophagy and necrosis in cancer are described.