Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction.
Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction.
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DOI：
10.1016/j.hrthm.2007.08.021
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发表时间：
2008
期刊：
影响因子：
5.5
通讯作者：
S. Saba;M. Mathier;H. Mehdi;Erdal Gursoy;Tong Liu;Bum-Rak Choi;G. Salama;B. London
中科院分区：
文献类型：
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作者：
S. Saba;M. Mathier;H. Mehdi;Erdal Gursoy;Tong Liu;Bum-Rak Choi;G. Salama;B. London
双心室（BIV）起搏可改善心力衰竭（HF）时的心功能，本研究采用新西兰白色家兔心肌梗死（MI）模型，探讨BIV起搏的作用机制（假手术[C]、无起搏的MI [MI]、右心室起搏的MI [MI+RV]和BIV起搏的MI [MI+BIV]），并进行连续心电图和超声心动图。第4周，切除心脏，从左心室（LV）的不同区域提取组织。冠状动脉结扎后4周，BIV起搏阻止了LV的收缩期和舒张期扩张以及其缩短分数的减少，使QRS宽度和频率依赖性QT间期恢复到其基线值，并阻止了ether-a-go-go（Erg）蛋白水平的下降。MI+RV组中没有记录这种重塑的预防。结论在BIV起搏和MI的兔子模型中，我们显示了心脏不良机械和电重塑的预防。这些变化可能是BIV起搏在更严重LV功能障碍的HF患者中观察到的一些受益的基础。
BACKGROUNDBiventricular (BIV) pacing can improve cardiac function in heart failure (HF).OBJECTIVEThis study sought to investigate the mechanisms of benefit of BIV pacing using a rabbit model of myocardial infarction (MI).METHODSNew Zealand White rabbits were divided into 4 groups (sham-operated [C], MI with no pacing [MI], MI with right ventricular pacing [MI+RV], and MI with BIV pacing [MI+BIV]) and underwent serial electrocardiograms and echocardiograms. At 4 weeks, hearts were excised and tissue was extracted from various areas of the left ventricle (LV).RESULTSFour weeks after coronary ligation, BIV pacing prevented systolic and diastolic dilation of the LV as well as the reduction in its fractional shortening, restored the QRS width and the rate-dependent QT intervals to their baseline values, and prevented the decline of the ether-a-go-go (Erg) protein levels. This prevention of remodeling was not documented in the MI+RV groups.CONCLUSIONIn this rabbit model of BIV pacing and MI, we show prevention of adverse mechanical and electrical remodeling of the heart. These changes may underlie some of the benefits seen with BIV pacing in HF patients with more severe LV dysfunction.