Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease
Interactions Between the Dietary Polyunsaturated Fatty Acid Ratio and Genetic Factors Determine Susceptibility to Pediatric Crohn's Disease
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DOI：
10.1053/j.gastro.2013.12.034
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发表时间：
2014-04-01
期刊：
影响因子：
29.4
通讯作者：
Amre, Devendra K.
中科院分区：
文献类型：
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作者：
Costea, Irina;Mack, David R.;Amre, Devendra K.
U6/U3多不饱和脂肪酸的膳食比例增加与克罗恩病(CD)的发病机制有关，但流行病学数据有限。我们调查了控制多不饱和脂肪酸代谢的基因变异(CYP4F3、FADS1和FADS2)以及U6/U3的饮食比例是否会增加Cd的易感性。基于182名新诊断为CD的儿童和250名对照儿童的数据，我们发现，饮食中U6/U3比例较高的儿童，如果他们同时携带特定的CYP4F3和FADS2基因变异体，就可能患上CD。我们的发现暗示了饮食-基因相互作用在CD的发病机制中的作用。
Increased dietary ratios of u6/u3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of u6/u3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of u6/u3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.