A systematic review of solid-pseudopapillary neoplasms: are these rare lesions?
A systematic review of solid-pseudopapillary neoplasms: are these rare lesions?
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DOI：
10.1097/mpa.0000000000000061
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发表时间：
2014-04
期刊：
影响因子：
2.9
通讯作者：
Lennon AM
中科院分区：
文献类型：
--
作者：
Law JK;Ahmed A;Singh VK;Akshintala VS;Olson MT;Raman SP;Ali SZ;Fishman EK;Kamel I;Canto MI;Dal Molin M;Moran RA;Khashab MA;Ahuja N;Goggins M;Hruban RH;Wolfgang CL;Lennon AM
The aim of the study was to determine if there had been any change in the number of solid-pseudopapillary neoplasms (SPN) cases detected, their evaluation or the management over time. A systematic review of SPN was performed of all articles published in English in PubMed and SCOPUS. 2,744 patients with SPN identified in 484 studies published between 1961-2012; 87.8% cases were reported between 2000-2012. 2,408 (87.8%) females and the mean age was 28.5 years (S.D. ± 13.7). The most common symptom was abdominal pain in 63.6% and incidentally detected in 38.1%. There were 2,285 patients who underwent pancreatic resection. The mean tumor size was 8.6 cm (S.D ± 4.3). Follow-up was reported for 1,952 (90.5%) patients, with mean follow-up of 36.1 months (S.D. ± 32.8). Disease-free survival was documented in 1,866 (95.6%) patients with recurrence in 86 (4.4%); median time to recurrence was 50.5 months. The number of SPNs reported in the literature has seen a 7-fold increase in the number of cases reported since 2000 compared to before. SPNs continue to be primarily found in young women and present with non-specific symptoms. Surgery remains the mainstay of treatment with an excellent long term prognosis.
