Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?
Integrin-linked kinase: a new member of the kinases involved in hypertensive end-organ damage?
复制标题
整合素连接激酶：参与高血压终末器官损伤的激酶的新成员？
DOI：
10.1042/cs20140081
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Eguchi,Satoru
中科院分区：
文献类型：
--
作者：
Obama,Takashi;Eguchi,Satoru
整合素连接激酶主要定位于粘着斑以调节肌动蛋白细胞骨架动力学，包括细胞迁移和基质重塑。尽管最近的研究表明整合素相关激酶在心血管和肾脏系统中的生理和病理生理作用，但其在高血压器官功能障碍（如肾脏功能障碍）中的作用尚未研究。在本期的《临床科学》杂志中，Alique及其同事证明，血管紧张素II诱导的肾脏炎症反应在条件性整合素连接激酶缺乏的小鼠中减弱，这与抑制核因子κB活化和活性氧的产生有关，但与高血压无关。本文就其意义、潜在机制和未来发展方向进行了阐述和讨论。
Integrin-linked kinase predominantly localizes at focal adhesions to regulate actin cytoskeletal dynamics, including cell migration and matrix remodelling. Although recent studies have suggested both physiological and pathophysiological roles of integrin-linked kinase in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue ofClinical Science, Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice with conditional deficiency of integrin-linked kinase, which were associated with suppression of nuclear factor κB activation and reactive oxygen species generation but not hypertension. The significance, potential mechanisms and future direction are presented and discussed in this Commentary.