Expression and clinical significance of antinuclear antibody in hepatitis C virus infection
Expression and clinical significance of antinuclear antibody in hepatitis C virus infection
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DOI：
10.1097/00004836-200111000-00012
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发表时间：
2001-11-01
影响因子：
2.9
通讯作者：
Chen, GH
中科院分区：
文献类型：
--
作者：
Peng, YC;Hsieh, SC;Chen, GH
背景：抗核抗体（ANA）在丙型肝炎病毒（HCV）感染患者中的流行已被证实。我们试图确定滴度和ANA的模式和临床意义的特点在HCV感染，研究：48例抗-HCV抗体阳性和HCV RNA阳性的患者被纳入本研究。采用间接免疫荧光法检测患者血清中抗核抗体（ANA）和抗平滑肌抗体。结果：48例HCV感染者中ANA阳性11例（23%），ANA阳性率为100%。11例ANA阳性HCV感染者中10例（91%）抗核抗体呈斑点状。37例ANA阴性HCV感染者中有20例（54%）可检测到可疑滴度（滴度
Background: The prevalence of antinuclear antibody (ANA) has been documented in patients with hepatitis C virus (HCV) infection. We attempted to determine the titer and to characterize the patterns and clinical significance of ANA in HCV infection, Study: Forty-eight consecutive patients with positive anti-HCV antibody and positive HCV RNA were included in this study. Sera from patients were tested for ANA and anti-smooth muscle antibody by indirect immunofluorescence. Serum aminotransferase, alkaline phophatase, alpha-fetoprotein, and cryoglobulin levels also were determined, Results: Eleven (23%) of 48 HCV-infected patients were positive for ANA. Antinuclear antibody revealed speckled pattern in 10 (91 %) of the 11 ANA-positive HCV-infected patients. Twenty (54%) of 37 ANA-negative HCV-infected patients had detectable pattern with equivocal titer (titer