Building Nanowires from Micelles: Hierarchical Self-Assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine
Building Nanowires from Micelles: Hierarchical Self-Assembly of Alternating Amphiphilic Glycopolypeptide Brushes with Pendants of High-Mannose Glycodendron and Oligophenylalanine
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从胶束构建纳米线：具有高甘露糖糖醛酸和寡苯丙氨酸悬垂物的交替两亲性糖多肽刷的分层自组装
DOI：
10.1021/jacs.6b05044
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发表时间：
2016-09-28
影响因子：
15
通讯作者：
Jiang, Ming
中科院分区：
文献类型：
--
作者：
Liu, Yijiang;Zhang, Yufei;Jiang, Ming
模拟自然界中各种各样的糖共轭结构一直是科学家们的梦想。目前，肽和糖的天然缀合物的分级自组装结构不能容易地通过以单糖作为附件的线性糖多肽实现。在这项工作中，通过使用一系列精心设计的交替的两亲性糖肽刷（AAGB）与糖基和短肽的悬垂物，实现了各种自组装形态，包括纳米线，纳米载体，和复合胶束主要取决于糖单元的数量比的氨基酸物种（S/F）。在这些形貌中，纳米线引起了我们极大的关注。TEM研究表明，它是通过分级自组装形成的，即，一系列连续的过程，包括胶束化、胶束排列形成纳米丝、通过胶束使纳米丝支化，以及最后形成纳米线。据我们所知，这种高度复杂的分级自组装过程在糖多肽甚至多肽的文献中还没有观察到，这将加深我们对天然糖缀合物自组装机制的理解，并扩大仿生材料库。
Mimicking the diverse glyco-conjugate structures in nature is always the dream of scientists. Right now, hierarchical self-assembled structures of natural conjugates of peptides and sugars could not easily be achieved via linear glycopolypeptide with monosaccharides as attachments. In this work, by using a series of well-designed alternating amphiphilic glycopolypeptide brushes (AAGBs) with pendants of glycodendrons and short peptides, various self-assembled morphologies were achieved, including nanowires, nanoribbon, and compound micelles mainly depending on the number ratio of the sugar units to the amino acids species (S/F). Among these morphologies, nanowire attracted our great attention. TEM studies demonstrated that it is formed via a hierarchical self-assembly, i.e., a series of successive processes, including micellization, micelles alignment forming nanofilament, branching of the nanofilaments by micelles, and finally nanowire formation. As far as we know, such hierarchical self-assembly process with high complexity has not been observed in literature for glycopolypeptides even polypeptides, which will deepen our understanding on self-assembly mechanism of natural glyco-conjugates and expand the library of biomimetic materials.