Aspirin resistance is more common in lacunar strokes than embolic strokes and is related to stroke severity
Aspirin resistance is more common in lacunar strokes than embolic strokes and is related to stroke severity
复制标题
DOI：
10.1038/jcbfm.2008.9
复制
发表时间：
2008-06-01
影响因子：
6.3
通讯作者：
Byrne, Christopher D.
中科院分区：
文献类型：
--
作者：
Englyst, Nicola A.;Horsfield, Gill;Byrne, Christopher D.
本研究的目的是探讨阿司匹林抵抗、缺血性卒中亚型、卒中严重程度和炎性细胞因子之间的关系。通过血栓弹力描记术对45例缺血性卒中患者和25例对照者的阿司匹林抵抗进行了评估。测定血浆白细胞介素（IL）-6。卒中严重程度采用改良兰金量表和国立卫生研究院卒中评分在卒中后72小时内进行评估。阿司匹林抵抗在卒中组比对照组更常见（67%比40%，P=0.028），并且在卒中组中，阿司匹林抵抗组的兰金评分更高（4.0比2.0，P=0.013）。腔隙性脑卒中患者阿司匹林抵抗率高于栓塞性脑卒中患者（血小板活化率分别为79%和59%，P=0.020）。中风阿司匹林抵抗组的IL-6水平高于中风阿司匹林敏感组（2.4 +/- 1 vs 1.8 +/- 0.9 ng/mL，P=0.037）。使用多变量分析，我们研究了阿司匹林抵抗、IL-6和卒中严重程度之间的相互关系。这些分析显示IL-6与卒中严重程度结局独立相关（B=3.738，P=0.036），阿司匹林抵抗与IL-6结局独立相关（B=0.765，P=0.005）。总之，阿司匹林抵抗与卒中严重程度相关，并且阿司匹林抵抗在腔隙性卒中中比栓塞性卒中更常见。
The aim of this study was to investigate the relationship between aspirin resistance, ischaemic stroke subtype, stroke severity, and inflammatory cytokines. Aspirin resistance was assessed by thrombelastography in 45 people with ischaemic stroke and 25 controls. Plasma interleukin (IL)-6 was measured. Stroke severity was assessed using the modified Rankin scale and National Institute of Health Stroke Score within 72 h of stroke. Aspirin resistance was more common in the stroke than the control group (67% versus 40%, P=0.028), and within the stroke group the aspirin-resistant group had a higher Rankin score (4.0 versus 2.0, P=0.013). Aspirin resistance was greater in lacunar than embolic strokes ( platelet activation 79% versus 59%, P=0.020). The stroke aspirin-resistant group had higher levels of IL-6 than the stroke aspirin-sensitive group (2.4 +/- 1 versus 1.8 +/- 0.9 ng/mL, P=0.037). Using multivariate analysis, we examined the interrelationships between aspirin resistance, IL-6, and stroke severity. These analyses showed that IL-6 was independently associated with stroke severity as the outcome (B=3.738, P=0.036), and aspirin resistance was independently associated with IL-6 (B=0.765, P=0.005) as the outcome. In conclusion, aspirin resistance is related to stroke severity and aspirin resistance is more common in lacunar strokes than embolic strokes.