Recirculating, suppressor T cells in transplantation tolerance
Recirculating, suppressor T cells in transplantation tolerance
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移植耐受中的再循环、抑制性 T 细胞
DOI：
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发表时间：
1977
影响因子：
15.3
通讯作者：
Bruce Roser
中科院分区：
文献类型：
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作者：
Susan Dorsch;Bruce Roser
使用过继转移系统来检查完全耐受 Ag-B 抗原的大鼠的细胞接种物将耐受性转移给受辐射受体的能力。这些受辐射的接受者的永久耐受性涉及对再生免疫反应的特异性抑制。从富含循环淋巴细胞的组织中获得的细胞是最有效的抑制剂。来自耐受供体的高度纯化的 T 细胞接种物在受辐射的宿主中是有效的抑制因子，但不能直接抑制外周抗原敏感 T 细胞。在耐受动物中胸腺在维持再循环抑制性 T 细胞补体中的作用在成年胸腺切除后进行了检查。胸腺切除的耐受大鼠不会排斥其耐受的移植物，并且通过证明胸腺切除耐受供体的细胞过继转移可有效抑制胸腺切除后长达 180 天的受辐射受体，证实了耐受大鼠的长期抑制作用。来自这些供体的细胞接种物失去抑制功能的速度似乎略快于失去效应功能的速度（通过它们介导第三方对照移植物排斥的能力来衡量）。胸腺切除术使耐受性大鼠更容易因正常细胞的攻击而终止耐受性。成年大鼠的移植耐受性是通过长寿命的快速再循环抑制性 T 细胞来维持的。这些细胞的抑制作用的目标可能是同种抗原敏感淋巴细胞的前体，并且抑制的效果可能是这些细胞的相关克隆的缺失或失活。
An adoptive transfer system was used to examine the capacity of cellular inocula from rats fully tolerant of Ag-B antigens to transfer tolerance to irradiated recipients. Permanent tolerance in these irradiated recipients involved specific suppression of the regenerating immune response. Cells obtained from tissues rich in recirculating lymphocytes were the most effective suppressors. Highly purified inocula of T cells from tolerant donors were potent suppressors in irradiated hosts, but were not capable of direct suppression of peripheral antigen-sensitive T cells.. The role of the thymus in maintaining the complement of recirculating suppressor T cells in tolerant animals was examined after adult thymectomy. Thymectomized tolerant rats did not reject their tolerated grafts, and the longevity of the suppression in tolerant rats was confirmed by showing that adoptive transfer of cells from thymectomized tolerant donors was effective in suppressing irradiated recipients up to 180 days after thymectomy. Cellular inocula from these donors appeared to lose their suppressor function marginally faster than they lost effector function (as measured by their capacity to mediate rejection of third party control grafts). Thymectomy made tolerant rats more vulnerable to the termination of tolerance by challenge with normal cells. Transplantation tolerance is maintained in adult rats by long-lived rapidly recirculating suppressor T cells. The target for the suppressor action of these cells is probably the precursor of alloantigen- sensitive lymphocytes, and the effect of suppression may be deletion or inactivation of the relevant clone of these cells.