How does multistep tumorigenesis really proceed?
How does multistep tumorigenesis really proceed?
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DOI：
10.1158/2159-8290.cd-14-0788
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发表时间：
2015-01
期刊：
影响因子：
28.2
通讯作者：
Weinberg RA
中科院分区：
文献类型：
--
作者：
Chaffer CL;Weinberg RA
识别癌细胞起源是非常有趣的，因为它具有阐明正常细胞状态中固有的生物学机制的潜力，这些机制已被增选以驱动致癌细胞状态。这里提出的一个新兴概念指出，癌症干细胞是癌症发生和转移的关键参与者，当具有突变基因组的过渡扩增细胞去分化并进入干细胞状态时，癌症干细胞就会出现。该模型与癌症干细胞是肿瘤转化的正常组织干细胞的直接产物的概念形成对比。
Identifying the cancer cells-of-origin is of great interest as it holds the potential to elucidate biological mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the stem cell state. This model contrasts with the notion that cancer stem cells are the direct products of neoplastically transformed normal tissue stem cells.