REDISTRIBUTION OF BLOOD-FLOW AFTER THERMAL-INJURY AND HEMORRHAGIC-SHOCK
REDISTRIBUTION OF BLOOD-FLOW AFTER THERMAL-INJURY AND HEMORRHAGIC-SHOCK
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DOI：
10.1152/jappl.1988.65.4.1782
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发表时间：
1988-10-01
影响因子：
3.3
通讯作者：
BURKE, JF
中科院分区：
文献类型：
--
作者：
CARTER, EA;TOMPKINS, RG;BURKE, JF
热损伤后，大鼠的肠粘膜粘膜质量减少，DNA 合成率降低。由于这些变化可能与缺血有关，因此研究了热损伤后肠道血流的分布，并与失血性休克后的血流分布进行了比较。对于热损伤，麻醉动物接受标准化的20%体表面积全层损伤，并进行腹腔盐水复苏。通过使用46Sc或141Ce标记的微球，热损伤后肠和肝血流没有发生变化。相反，失血性休克后发现血流明显重新分布，其中流向胃、小肠和大肠的动脉血流减少。尽管不存在临床休克，但失血性休克和热损伤时心输出量下降到相当程度。这些研究表明，虽然烧伤后肠粘膜发生生理变化，但这些变化并不是由于肠系膜动脉血流减少所致。
Diminished mucosal mass and a diminished rate of DNA synthesis by the intestinal mucosa have been identified in the rat after thermal injury. Because these changes may be associated with ischemia, the distribution of intestinal blood flow was studied after a thermal injury and compared with the blood flow distribution after hemorrhagic shock. For the thermal injury, anesthetized animals received a standardized 20% body surface area, full-thickness injury and were given intraperitoneal saline resuscitation. By the use of 46Sc- or 141Ce-labeled microspheres, no changes in intestinal and hepatic blood flow occurred after thermal injury. In contrast, a marked redistribution of blood flow was identified after hemorrhagic shock in which a decrease in arterial blood flow was identified to the stomach and to the small and large intestine. Although clinical shock was not present, the cardiac output decreased to a comparable degree in the hemorrhagic shock and the thermal injury. These studies indicate that although physiological changes in intestinal mucosa can be demonstrated after burn injury, these changes are not due to decreases in mesenteric arterial blood flow.