Drug-induced liver disease
Drug-induced liver disease
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DOI：
10.1097/00001574-199905000-00005
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发表时间：
1999-05-01
影响因子：
2.5
通讯作者：
Zimmerman, H
中科院分区：
文献类型：
--
作者：
Mayoral, W;Lewis, JH;Zimmerman, H
去年，引起肝损伤的药物清单中增加了一些药物。许多这些药物会导致暴发性肝坏死，在某些情况下已从市场上撤出（例如溴芬酸）。其他药物在标签中附有警告以及严格的监测指南，以提醒医生和患者可能造成严重肝损伤（例如曲格列酮、托卡朋）。关于许多老药物的肝毒性的新报告不断出现，在某些情况下扩大了药物的肝毒性谱。胆管消失综合征引起了越来越多的关注，目前与 30 多种药物有关。布洛芬是新近被描述为引起这种综合征的药物之一，据报道丙型肝炎病毒感染是布洛芬肝毒性的可能危险因素，这引发了对患有潜在肝病的患者安全使用非处方药和处方药的问题。除了成人治疗意外的病例外，已有数十名儿童因无意过量服用对乙酰氨基酚而引起肝毒性的报道。 (C) 1999 Lippincott Williams & Wilkins, Inc.
The past year has seen several additions to the list of drugs that cause hepatic injury. Many of these agents produce fulminant hepatic necrosis and, in some cases, were withdrawn from the market (eg, bromfenac). Other drugs had warnings placed in their labeling along with stringent monitoring guidelines to alert physicians and patients alike to the potential for severe hepatic injury (eg, troglitazone, tolcapone). New reports of hepatoxicity continued to appear for many older agents, in some cases expanding the hepatotoxic spectrum for the drugs. Vanishing bile duct syndrome has drawn increasing attention and is now associated with more than 30 drugs. Ibuprofen is among those drugs newly described as causing this syndrome, Hepatitis C virus infection was reported as a possible risk factor for ibuprofen hepatotoxicity, raising the issue of safe use of nonprescription as well as prescription drugs in patients with underlying liver disease. Reports have appeared about acetaminophen-induced hepatotoxicity in several dozen children from unintentional overdoses, in addition to cases of therapeutic misadventure in adults. (C) 1999 Lippincott Williams & Wilkins, Inc.