Cavum Septum Pellucidum in Retired American Pro-Football Players
Cavum Septum Pellucidum in Retired American Pro-Football Players
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DOI：
10.1089/neu.2014.3805
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Rabinovici, Gil D.
中科院分区：
文献类型：
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作者：
Gardner, Raquel C.;Hess, Christopher P.;Rabinovici, Gil D.
以往的研究报道，透明隔腔（CSP）在有重复创伤性脑损伤（TBI）病史的运动员中很常见，如拳击手。然而，很少有关于运动员CSP的研究以病例对照的方式评估了透明隔的详细特征。这一点很重要，因为在不同的研究中，普通人群中CSP的患病率差异很大（2%至85%）。此外，美国职业橄榄球运动员中CSP的发病率以前没有被描述过。与对照组相比，我们试图描述一系列有反复脑震荡/次脑震荡历史的退役职业足球运动员的透明隔的MRI特征。我们回顾性地评估了到我们的记忆诊所就诊的有认知/行为症状的退役美国职业橄榄球运动员，他们在断层厚度为2mm时进行了结构MRI检查（n=17）。每个参与者都与一个没有创伤性脑损伤病史的记忆诊所对照患者相匹配。扫描结果由不了解临床信息和TBI/足球病史的评分者解读，他们根据标准方案测量CSP等级（0-缺失，1-模糊，2-轻度，3-中度，4-重度）和长度。17名玩家中有16名（94%）拥有2级CSP，而17名对照组中有3名（18%）拥有2级CSP。CSP的分级显著增高(p
Previous studies report that cavum septum pellucidum (CSP) is frequent among athletes with a history of repeated traumatic brain injury (TBI), such as boxers. Few studies of CSP in athletes, however, have assessed detailed features of the septum pellucidum in a case-control fashion. This is important because prevalence of CSP in the general population varies widely (2% to 85%) between studies. Further, rates of CSP among American pro-football players have not been described previously. We sought to characterize MRI features of the septum pellucidum in a series of retired pro-football players with a history of repeated concussive/subconcussive head traumas compared with controls. We retrospectively assessed retired American pro-football players presenting to our memory clinic with cognitive/behavioral symptoms in whom structural MRI was available with slice thickness 2mm (n=17). Each player was matched to a memory clinic control patient with no history of TBI. Scans were interpreted by raters blinded to clinical information and TBI/football history, who measured CSP grade (0-absent, 1-equivocal, 2-mild, 3-moderate, 4-severe) and length according to a standard protocol. Sixteen of 17 (94%) players had a CSP graded 2 compared with 3 of 17 (18%) controls. CSP was significantly higher grade (p