Feasibility of In Vivo Measurement of Carotid Wall Shear Rate Using Spiral Fourier Velocity Encoded MRI
Feasibility of In Vivo Measurement of Carotid Wall Shear Rate Using Spiral Fourier Velocity Encoded MRI
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DOI：
10.1002/mrm.22325
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发表时间：
2010-06-01
影响因子：
3.3
通讯作者：
Nayak, Krishna S.
中科院分区：
文献类型：
--
作者：
Carvalho, Joao L. A.;Nielsen, Jon-Fredrik;Nayak, Krishna S.
动脉壁切应力被广泛认为影响动脉粥样硬化斑块的形成和生长，然而，目前还没有活体测量的金标准。由于部分体积效应和所需高空间分辨率下的信噪比不足，相位对比MRI的使用已被证明是具有挑战性的。这项工作评估了螺旋傅立叶速度编码MRI作为一种快速评估颈动脉壁剪切率的方法的使用。使用Frayne和Rutt开发的方法(Magn Reson Med 1995；34：378-387)，根据跨越血管/血管壁界面的体素中的速度直方图计算壁剪切率。本研究(I)证明了与高分辨率相位对比相比，螺旋傅立叶速度编码在搏动性颈动脉血流模型中测量的速度直方图的准确性，(Ii)证明了在使用颈动脉计算流体力学模拟设计的数值模型中基于傅立叶速度编码的切变率测量的准确性，以及(Iii)在3TMagn Reson Med 63：1537-1547,2010在健康志愿者的颈动脉中活体测量局部壁切变速率和振荡切变指数。(C)2010年Wiley-Liss公司
Arterial wall shear stress is widely believed to influence the formation and growth of atherosclerotic plaque; however, there is currently no gold standard for its in vivo measurement. The use of phase contrast MRI has proved to be challenging due to partial-volume effects and inadequate signal-to-noise ratio at the high spatial resolutions that are required. This work evaluates the use of spiral Fourier velocity encoded MRI as a rapid method for assessing wall shear rate in the carotid arteries. Wall shear rate is calculated from velocity histograms in voxels spanning the blood/vessel wall interface, using a method developed by Frayne and Rutt (Magn Reson Med 1995;34:378-387). This study (i) demonstrates the accuracy of the velocity histograms measured by spiral Fourier velocity encoding in a pulsatile carotid flow phantom compared with high-resolution phase contrast, (ii) demonstrates the accuracy of Fourier velocity encoding-based shear rate measurements in a numerical phantom designed using a computational fluid dynamics simulation of carotid flow, and (iii) demonstrates in vivo measurement of regional wall shear rate and oscillatory shear index in the carotid arteries of healthy volunteers at 3 T. Magn Reson Med 63:1537-1547, 2010. (C) 2010 Wiley-Liss, Inc.