Acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) versus acupuncture or NSAIDs alone for the treatment of chronic neck pain: an assessor-blinded randomised controlled pilot study
Acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) versus acupuncture or NSAIDs alone for the treatment of chronic neck pain: an assessor-blinded randomised controlled pilot study
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DOI：
10.1136/acupmed-2013-010410
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发表时间：
2014-02-01
影响因子：
2.5
通讯作者：
Lee, Jun-Hwan
中科院分区：
文献类型：
--
作者：
Cho, Jae-Heung;Nam, Dong-Hyun;Lee, Jun-Hwan
目的探讨针刺联合非甾体类抗炎药（NSAIDs）治疗慢性颈痛与单纯针刺或NSAIDs治疗疗效的全面随机对照试验的可行性和所需样本量。针刺加NSAIDs治疗组在每周3次针刺治疗的同时，每日服用NSAIDs（扎托洛芬，80 mg），共治疗3周。针刺治疗组每周治疗3次，NSAID治疗组每日服用NSAID。主要结局是确定可行性和计算样本量。作为次要结局，疼痛强度和疼痛相关症状的慢性颈部pain.Results招募和脱落率方面，88.2%的患者同意被招募到试验和15.6%的参与者失去了后续行动。全规模试验的样本量估计为120例患者。尽管是初步的，但所有组中基线测量值和每个评估点之间颈部疼痛强度的视觉模拟量表（VAS）均发生显著变化。然而，有三个groups.Conclusions之间的VAS评分没有差异，这项试点研究提供了一个全面的试验，针灸与非甾体类抗炎药治疗慢性颈部疼痛相比，针灸或非甾体类抗炎药治疗的可行性和样本量。需要进一步的研究来验证针灸与非甾体抗炎药的作用。ClinicalTrials.gov
Objective To investigate the feasibility and sample size required for a full-scale randomised controlled trial of the effectiveness of acupuncture with non-steroidal anti-inflammatory drugs (NSAIDs) for chronic neck pain compared with acupuncture or NSAID treatment alone.Methods A total of 45 patients with chronic neck pain participated in the study. For 3weeks the acupuncture with NSAIDs treatment group took NSAIDs (zaltoprofen, 80mg) daily while receiving acupuncture treatment three times a week. The acupuncture treatment group received treatment three times a week and the NSAID treatment group took NSAIDs daily. The primary outcomes were to determine the feasibility and to calculate the sample size. As secondary outcomes, pain intensity and pain-related symptoms for chronic neck pain were measured.Results With regard to enrolment and dropout rates, 88.2% of patients consented to be recruited to the trial and 15.6% of participants were lost to follow-up. The sample size for a full-scale trial was estimated to be 120 patients. Although preliminary, there was a significant change in the visual analogue scale (VAS) for neck pain intensity between the baseline measurement and each point of assessment in all groups. However, there was no difference in VAS scores between the three groups.Conclusions This pilot study has provided the feasibility and sample size for a full-scale trial of acupuncture with NSAIDs for chronic neck pain compared with acupuncture or NSAID treatment alone. Further research is needed to validate the effects of acupuncture with NSAIDs.Clinical Trial Registration NIH ClinicalTrials.gov NCT01205958.